Research Groups

Endometrial cancer (EC)

A project aimed to study molecular mechanisms of developing familial endometrial cancer (EC) in Bulgaria has been conducted. Clinical and biological materials from 150 patients with EC were collected and genetically characterized by analysis for MSI, promoter hypermethylation of the hMLH1 gene, immunohistochemistry and screening for mutations in the main MMR genes. We were able to propose an optimal strategy for early diagnosis of EC in and to initiate a familial register.

Our future interests in this direction are to conduct an examination of the role of specific candidate genes (SNPs analysis) in endometrial cells for the early diagnosis of endometriosis. This will help to identify risk factors, correlated to the occurrence of the disease and the aggressiveness of the proliferative process, which in turn correlates to the prognosis.

Clinical collaborators:

Assoc. Prof. Nicolay Doganov, MD, PhD - Department of Obstetrics and Gynaecology;

Karela Mainkhard, MD - Department of Pathology, Laboratory of Gynaecology, Pathology and Neonatology;

Assoc. Prof. Eliza Tiufeckchieva, MD, PhD - First Gynaecology Clinic;

Roumen Dimitrov, MD, PhD – Department of Obstetrics and Gynaecology, University Hospital of Obstetrics and Gynaecology “Maichin dom”, Sofia,

Prof. Stefan Ivanov, MD, PhD - Department of Gynaecology, Medical University – Varna .