Laryngeal squamous cell carcinoma (LSSC)
Laryngeal squamous cell carcinomas are characterized by high risk of locoregional recurrence and second primary tumours, especially in the first two years after primary diagnosis. Also, LSCC have high mortality rate. Numerous genetic and genomic alterations have been described in LSCC, but the exact molecular mechanisms predicting progression of LSCC are still poorly understood. Recently, a study on promoter hypermethylation of 3 genes – CDKN2A, MLH1 and MGMT was conducted in MMC in a search for a link between decreased gene expression and biological behaviour of the tumour.
In 2010 a project funded by FNI, MON was started. The aim of the project is investigation on mutations in several genes (CDKN2A, TP53), gene expression and HPV involvement in carcinogenesis.
Prof. Kuncho Kunev, MD, PhD, Head of ENT Department,
Assoc. Prof. Ivan Chalakov, MD, PhD,
Stanislav Jordanov, MD, PhD student, Clinic of Otorhinolaryngology, University Hospital „Tsaritsa Yoanna”.