About / Lab Staff


Gergana Stefanova Stancheva

Education:

2009~ PhD student in Molecular Medicine Center, Sofia, Bulgaria

2008 Master s Degree in Genetics- Sofia University St. Kliment Ohridski, Faculty of Biology, Sofia, Bulgaria

2006 Bachelor s Degree in olecular biology - Sofia University St. Kliment Ohridski, Faculty of Biology, Sofia, Bulgaria

Previous and Current Employment:

12.2009~ PhD student, Sofia, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia

06.2009–02.2010 Laboratory technician Genetics, Molecular Medicine Center Medical University - Sofia

04.2008-06.2009 Biological technologist (monitor), Milray JSC

Language proFiciency:

English, Spanish

Research interests:

Oncogenetics, Gene expression in cancer, Genetics of multifactorial diseases

Participation in research projects:

Principal Investigator

2012-2013 Expression analysis of CAIX, MMP-9 and TGF-?2 genes and their applicability as prognostic markers in malignant glial tumors

2011-2012 Investigation of IDH1, IDH2 and TP53 genes and 1p/19q chromosomal deletions in Bulgarian patients with malignant glial tumors,

2010-2011 Genetic markers with prognostic value in malignant glial tumors

Co-Investigator

2011-2014 Genomic analysis of mutations in patients with congenital anomalies of the kidney and urinary tract (CAKUT)

2010-2012 Analysis of clinical and molecular characteristics of laryngeal squamous cell carcinoma and their application for prediction of prognosis and treatment response

2010-2012 Follow up of circulating tumor cells (CTC) levels in patients with metastatic breast carcinoma - prognostic and predictive meaning

2010-2013 National University Complex in Biomedical and Translational Research, infrastructural project

2008-2010 Enhancing the capacity of the Molecular Medicine Center, Medical University-Sofia for functional genomic, proteomic and metabolomic research

2009-2011 Clinical and molecular markers with predictive value for survival, quality of life and treatment response in high-grade gliomas

2009-2011 Contemporary approaches for unravelling the genetic basis of epilepsy

2009-2010 Squamous cell carcinoma of the larynx and the hypopharynx. Genetic defects associated with carcinogenesis and biological behaviour of the tumour

Publications:

1. Kote-Jarai Z, et al. The PRACTICAL Consortium (In Supplementary Information – G. Stancheva). Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics 2011; 43:785–791.

2. T. Vlaykova, A. Mitkova, G. Stancheva , T. Kadiyska, M. Gulubova, Y. Yovchev, G. Cirovski, P. Chilingirov, E. Kostadinov, D. Damyanov, I. Kremensky, V. Mitev, R. Kaneva. (2010) Microsatellite instability and promotor hypermethylation of MSH1 and MSH2 in Bulgarian patients with sporadic colorectal cancer. Scheduled for Vol.16, no.2, 2011 issue of J BUON

 

 

Presentations:

1. G. Stancheva, T. Goranova, M. Laleva, M. Kamenova, A. Mitkova, N. Velinov, R. Kaneva, G. Poptodorov, V. Mitev, N. Gabrovsky. Molecular biomarkers with predictive value in glioma patients Poster presentation. The 10th Meeting of European Association of Neurooncology, 06-09 September 2012, Marseille, France

2. G. Stancheva, T. Goranova, M. Laleva, M. Kamenova, A. Mitkova, N. Velinov, R. Kaneva, G. Poptodorov, V. Mitev, N. Gabrovsky. MLPA analysis of 1p/19q deletion in patients with astrocytoma and oligodendrogliomas. The 22nd Meeting of European Association for Cancer Research, 7-10 July 2012, Barcelona, Spain.

3. T. Todorova, S. Jordanov, G. Stancheva, A. Mitkova, I. Chalakov, R. Kaneva, V. Mitev, M. Melnicharov and T. Goranova. Genetic aberrations in CDKN2A and TP53 genes in patients with laryngeal carcinoma. The 22nd Meeting of European Association for Cancer Research, 7-10 July 2012, Barcelona, Spain.

4. G. Stancheva, T. Goranova, M. Laleva, M. Kamenova, A. Mitkova, N. Velinov, R. Kaneva, G. Poptodorov, V. Mitev, N. Gabrovsky. A novel missense mutation in IDH2 gene of a glioma patient. The European Human Genetics Conference, 22-26 June 2012, Nuremberg, Germany. /Eur J Hum Genet, 2012, 20 (suppl 1): 166, P06.48/

5. Stefano Pierini, Teodora Goranova, Gergana Stancheva, Maria Laleva, Margarita Kamenova, Atanaska Mitkova, Nikolay Velinov, Radka Kaneva, George Poptodorov, Vanio Mitev, Nikolay Gabrovsky. MGMT promoter hypermethylation is a frequent event in glioma patients but has no prognostic value. The European Human Genetics Conference, 22-26 June 2012, Nuremberg, Germany. /Eur J Hum Genet, 2012, 20 (suppl 1): 186, P06.144/

6. G. Stancheva, T. Goranova, M. Laleva, N. Velinov, R. Kaneva, G. Poptodorov, V. Mitev, St. Gabrovsky, P.Vanev, N. Gabrovsky. Comparison of instruments for quality of life measurement in Bulgarian patients with malignant glial tumors. The 2011 European Multidisciplinary Cancer Congress, 23-27 September 2011, Stockholm, Sweden. /Eur J Cancer, September 2011, Vol 47 (suppl 1), page S579, 8715/

7. M. Stefanova, S. Jordanov, R. Tzveova, G. Stancheva, A. Mitkova, I. Chalakov, R. Kaneva, V. Mitev and T. Goranova. The prevalence of microsatellite instability and loss of heterozygosity in Bulgarian patients with laryngeal carcinoma. The 2011 European Multidisciplinary Cancer Congress, 23-27 September 2011, Stockholm, Sweden. /Eur J Cancer, September 2011, Vol 47 (suppl 1), page S551, 8525/

8. Gergana Stancheva, Reni Tzveova, Stanislav Jordanov, Atanaska Mitkova, Ivan Chalakov, Radka Kaneva, Vanio Mitev and Teodora Goranova. Promoter hypermethylation of CDKN2A gene in Bulgarian patients with Laryngeal Squamous Cell Carcinoma Poster presentation. The 4th International Congress of Molecular Medicine27-30 June 2011, Istanbul, Turkey. /In vivo 25:560 (2011)

9. Teodora Goranova, Gergana Stancheva, Atanaska Mitkova, Radka Kaneva, Margarita Kamenova, Maria Laleva, Nikolay Velinov, George Poptodorov, Vanio Mitev, Nikolay Gabrovsky. MGMT promoter methylation in Bulgarian patients with glial tumors Poster presentation. The 4th International Congress of Molecular Medicine27-30 June 2011, Istanbul, Turkey. /In vivo 25: 526 (2011)/

10. G. Stancheva, T. Goranova, M. Laleva, M. Kamenova, A. Mitkova, N. Velinov, R. Kaneva, G. Poptodorov, V. Mitev and N. Gabrovsky. IDH1, IDH2 and TP53 mutations in Bulgarian patients with glial tumours. Poster presentation. European Human Genetics Conference 2011 28-31 May 2011, Amsterdam, The Netherlands. /Eur J Hum Genet, 2011, 19 (suppl 2): 198, P06.042/

11. R. Tzveova, G. Stancheva, S. Jordanov, A. Mitkova, I. Chalakov, R. Kaneva, V. Mitev and T. Goranova. Promoter hypermethylation of DNA repair genes in Bulgarian patients with laryngeal carcinoma. Poster presentation. European Human Genetics Conference 2011 28-31 May 2011, Amsterdam, The Netherlands. /Eur J Hum Genet, 2011, 19 (suppl 2): 217, P06. 122/

12. T. Goranova, G. Stancheva, A. Mitkova, R. Kaneva, G. Poptodorov, N. Velinov, V. Mitev, N. Gabrovsky. Mutations in IDH1 and TP53 as prognostic biomarkers in Bulgarian patients with gliomas Poster presentation. The 9th Meeting of European Association of Neurooncology 16-19 September 2010, Maastricht, The Netherlands.

13. T. Goranova, G. Stancheva, A. Mitkova, R. Kaneva, G. Poptodorov, N. Velinov, V. Mitev, N. Gabrovsky. IDH1 and IDH2 mutations in Bulgarian patients with glial tumours Poster presentation. The 21st Meeting of European Association for Cancer Research 26-29 June 2010, Oslo, Norway.

14. G. Stancheva, T. Goranova, S. Jordanov, A. Mitkova, I. Chalakov, G. Poptodorov, R. Kaneva, V. Mitev, N. Gabrovsky, K. Kunev. Promoter hypermethylation in Bulgarian patients with glial and laryngeal cancer Poster presentation. The 21st Meeting of European Association for Cancer Research 26-29 June 2010, Oslo, Norway.

15. Mitkova A, Stancheva G, Goranova T, Kadiyska T, Kostadinov E, Vlaykova T, Gulubova M, Damyanov D, Mitev V, Kaneva R. Large genomic aberrations in MSH2 and MLH1 genes in Bulgarian colorectal cancer patients European Association for Cancer Research, 26-29 June 2010, Oslo, Norway

16. Vlaykova T, Gulubova M, Mitkova A, Stancheva G, Vlaykova D, Cirovski G, Yovchev Y, Chilingirov P, Kaneva R. Microsatellite instability may have a positive effect on the prognosis of patients with colorectal cancer. International Scientific Conference, Stara Zagora, (5-6 June, 2008). Union of Scientists – Stara Zagora, Proceeding (electron version-CD)

17. Mitkova, A.V, Vlajkova T, Stancheva G. et al. (2008) Microsatellite instability and promotor hypermethylation of MLH1 and MSH2 in Bulgarian patients with sporadic colorectal cancer European J. Human Genet. 16(2): 193.