About / Lab Staff
Daniela Rosenova Dacheva
Education:
2012- PhD student, Department of Medical Chemistry and Biochemistry, Medical University Sofia
2011- MSc in Biotechnology and Gene and Cell Engineering - Sofia University St. Kliment Ohridski, Faculty of Biology
2009- Bachelor in Molecular Biology - Sofia University St. Kliment Ohridski, Faculty of Biology
Previous and Current Employment:
2011 – Laboratory manager, Molecular Medicine Centre, Medical University, Sofia
Language proficiency:
English
Research interests:
Oncogenetics, Genetics of multifactorial disorders, Molecular biology, DNA diagnostics, gene expression in cancer
Participation in research projects:
Co-Investigator
2011-2013 Genomic mutation analysis in patients with congenital anomalies of the kidney and urinary tract (CAKUT)
2010-2013 Follow up of circulating tumor cells (CTC) levels in patients with metastatic breas carcinoma- prognostic and predictive meaning.
2011-2012 Analysis of mutations in BRCA1 gene in Bulgarian patients with triple negative breast cancer
2011-2012 Study of mutations in HFE gene in patients with chronic liver diseases with or without iron overload syndrome
2011-2013 Study of the role of genomic aberrations, deletions and duplications in the pathology of congenital anomalies of the kidney and urinary tract (CAKUT)
2012-2013 Introduction of mutational screening for transcription factors POU1F-1 ( PIT1), HESX1, SOX3 in patients with congenital hiposomatotropism
Publications:
· А. Tsanova, D. Dacheva, V. Penchev, G. As. Georgiev, T. Pajpanova, E. Golovinski and Z. Lalchev. Comparative study of the interaction between synthetic methionine-enkephalin and monolayers of zwitterionic and negatively charged phospholipids. Biotechnology & Biotechnological Equipment 2009; Volume 23, Number 2, pp. 463-466
· A. Tsanova, A. Jordanova, D. Dacheva, V. Penchev, R. Georgieva, E. Stoimenova, G. Georgiev, Z. Lalchev. Interaction of synthetic neuropeptides with lipid monolayers. Annual of The Constantine of Preslav University of Shumen 2009
Presentations:
· Daniela Dacheva, Rumyana Dodova, Atanaska Mitkova, Aleksandrina Vlahova, Tihomir Dikov, Spartak Valev, Constanta Timcheva, Svetlana Christova, Vanio Mitev, and Radka Kaneva. Mutation screening of BRCA2 exon 11 and exon 17 in Bulgarian breast cancer patients. Poster presentation. The European Association for Cancer Research, 7-10 July 2012, Barcelona, Spain.
· Rumyana Dodova, Daniela Dacheva,, Aleksandrina Vlahova, Tihomir Dikov, Svetlana Christova, Spartak Valev, Margarita Taushanova, Constanta Timcheva, Radka Kaneva and Atanaska Mitkova. Mutation screening of BRCA1 gene in Bulgarian breast cancer patients Poster presentation. The European Association for Cancer Research, 7-10 July 2012, Barcelona, Spain.
· Daniela Dacheva, Rumyana Dodova, Aleksandrina Vlahova, Tihomir Dikov, Svetlana Christova, Spartak Valev, Constanta Timcheva, Vanio Mitev, Radka Kaneva and Atanaska Mitkova. Mutation screening of BRCA2 exons 11 in Bulgarian breast cancer patients. Poster presentation. The European Human Genetics Conference, 28-31 May 2011, Amsterdam, The Netherlands.
· Rumyana Dodova, Daniela Dancheva, Aleksandrina Vlahova, Tihomir Dikov, Svetlana Hristova, Spartak Valev, Constanta Timcheva, Vanio Mitev, Radka Kaneva, and Atanaska Mitkova. Large genomic aberrations in BRCA1 and BRCA2 genes in Bulgarian breast cancer patients. Poster presentation. The European Human Genetics Conference, 28-31 May 2011, Amsterdam, The Netherlands.
· Rumyana Dodova, Atanaska Mitkova, Daniela Dacheva, Marija Caulevska, Aleksandrina Vlahova, Tihomir Dikov, Spartak Valev, Margarita Taushanova, Constanta Timcheva, Vanio Mitev, Radka Kaneva and Svetlana Christova. BRCA mutation screening in Bulgarian breast cancer patients. Poster presentation European Congress of Pathology (ECP) 27 August - 01 September 2011, Helsinki, Finland
· V. Penchev, D. Gulenova, D. Dacheva, M. Popova, G. Nikolov. Correlations between the integrity of the sperm genome and morphological characteristics of spermatozoa in the sperm. Oral presentation. XII Congress of Infertility, Contraception and Hormone Replacement Therapy 2010. Plovdiv, Bulgaria
· А. Tsanova, D. Dacheva, V. Penchev, G. As. Georgiev, T. Pajpanova, E. Golovinski and Z. Lalchev. Comparative study of the interaction between Met-enkephalin analogues and monolayer of zwitterionic and negatively charged phospholipids. Poster presentation. 11th International Congress on Amino Acids, Peptides and Proteins 2009, Vienna, Austria
· А. Tsanova, D. Dacheva, V. Penchev, G. As. Georgiev, T. Pajpanova, E. Golovinski and Z. Lalchev. Comparative study of the interaction between synthetic Met-enkephalin and monolayer of zwitterionic and negatively charged phospholipids. Poster presentation. XI Anniversary Science Conference "Biology – tradition and challenges" , 27 - 29 May 2009, Sofia, Bulgaria
· А. Tsanova, D. Dacheva, V. Penchev, A. Jordanova G. As. Georgiev, T. Pajpanova, E. Golovinski and Z. Lalchev. Interaction of ?-cyclodextrin on the penetration ability of Met-enkephalin in lipid monolayer. Poster presentation. International Science Conference “Developing the economy and society based on knowledge , Stara Zagora, Bulgaria 2009
