About / Lab Staff
Chief Assist. Prof. Olga Jivanova Beltcheva, PhD
Name:
Olga Jivanova Beltcheva
Education:
2005 PhD degree in Medical Biochemistry– Karolinska Institute, Stockholm, Sweden
1997 MSc degree in Biology; Cell and Developmental Biology– Sofia University, Biology Faculty, Sofia, Bulgaria
Previous and Current Employment:
2009~ Assistant Professor in Department of Medical Chemistry and Biochemistry, Medical University – Sofia, Sofia, Bulgaria
2006 Post-doctoral fellow in Molecular Medicine Center, Sofia, Bulgaria
2005 Post-doctoral fellow in Karolinska Institute, Stockholm, Sweden
2000- 2005 PhD student in Karolinska Institute, Stockholm, Sweden
1998-1999 Research scientist in Oulu University, Oulu, Finland
1998 Research scientist in Laboratory of Molecular Pathology, Medical University – Sofia, Sofia, Bulgaria
Language proficiency:
English, Swedish, Russian
Research interests:
Genetics of multifactorial disorders; population genetics; gene regulation; kidney development and disorders
Participation in research projects:
Principal Investigator
2011-2013 Genomic mutation analysis in patients with congenital anomalies of the kidney and urinary tract (CAKUT)
2009-2010 Study of the role of hepatocyte nuclear factor 1-beta (HNF1b) for the development of congenital anomalies of the kidney and urinary tract,
2008-2009 Frequency and characteristics of the WT1 gene mutations in patients with steroid-resistant nephrotic syndrome,
2007-2008 Role of the podocin gene (NPHS2) mutations for the pathology of steroid-resistant nephrotic syndrome and microalbuminuria population risk in Bulgaria,
Co-Investigator
2012-2013 Study of the role of candidate genes SKAP2, SUMF1, CROCC and TNS1 in the pathogenesis of congenital anomalies of the kidney and urinary tract
2009-2012 National University Complex in Biomedical and Translational Research, infrastructural project
2011-2012 Study of the role of genomic rearrangements, deletions and duplications, for the pathology of congenital anomalies of the kidney and urinary tract (CAKUT).
2009-2011 Contemporary approach for diagnostics, frequency assessment and genotype-phenotype correlations in patients with gestational diabetes mellitus in Bulgarian population
2010-2011 Study of the molecular basis of congenital anomalies of the kidney and urinary tract (CAKUT) in Bulgaria. Role of Pax2 for the pathogenesis of CAKUT
2010-2011 Enhancing the capacity of the cores Cell and Tissue Cultures, Microarray and Laser Microdissection in Molecular Medicine Center, MU - Sofia, infrastructural project
2009-2011 Study of the genetic variations, associated with increased risk and identification of diagnostics and prognostics markers for prostate cancer
2006-2011 Genetic epidemiology of opiate dependence in Bulgaria, NIDA NIH grant
2008-2010 Enhancing the capacity of the Molecular Medicine Center, Medical University-Sofia for functional genomic, proteomic and metabolomic research
2009-2010 Genetic, neuropsychological and vascular markers for early detection of Alzheimer s Disease
2006-2008 Establishing a SNP Genotyping and Gene Expression Core at Molecular Medicine Centre, Medical University, Sofia
Publications:
1. Beltcheva O, Boueva A., Tzveova R,Roussinovb D, Marinovab S, Kaneva R, Mitev V. Steroid-resistant nephrotic syndrome caused by novel WT1 mutation inherited from a mosaic parent, Renal failure, in press
2. R. Tzveova, Naydenova G., Yaneva T, Dimitrov G., Vandeva S., Matrozova Y., Pendicheva-Duhlenska D., Popov I., Beltheva O., Naydenov C., Tarnovska-Kadreva R., Nachev G., Mitev V., Kaneva K. Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients Biochem Genet, 2015
3. Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Muller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nothen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerstrom N, Scherbaum N, Schmal C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafo MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet. 2015
4. Amin Al Olama A, Benlloch S, Antoniou AC, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Muir K, Schleutker J, Henderson BE, Haiman CA, Schumacher FR, Pashayan N, Pharoah PD, Ostrander EA, Stanford JL, Batra J, Clements JA, Chambers SK, Weischer M, Nordestgaard BG, Ingles SA, Sorensen KD, Orntoft TF, Park JY, Cybulski C, Maier C, Doerk T, Dickinson JL, Cannon-Albright L, Brenner H, Rebbeck TR, Zeigler-Johnson C, Habuchi T, Thibodeau SN, Cooney KA, Chappuis PO, Hutter P, Kaneva RP, Foulkes WD, Zeegers MP, Lu YJ, Zhang HW, Stephenson R, Cox A, Southey MC, Spurdle AB, FitzGerald L, Leongamornlert D, Saunders E, Tymrakiewicz M, Guy M, Dadaev T, Little SJ, Govindasami K, Sawyer E, Wilkinson R, Herkommer K, Hopper JL, Lophatonanon A, Rinckleb AE, Kote-Jarai Z, Eeles RA, Easton DF; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci. Cancer Epidemiol Biomarkers Prev. 2015
5. Done SC, Beltcheva O. In situ hybridization detection of miRNA using LNA™ oligonucleotides. Methods Mol Biol. 2014; 1182:57-71.
6. Beltcheva O, Boyadzhieva M, Angelova O, Mitev V, Kaneva R, Atanasova I. The rs266729 single-nucleotide polymorphism in the adiponectin gene shows association with gestational diabetes. Arch Gynecol Obstet. 2014 Apr;289(4):743-8. doi: 10.1007/s00404-013-3029-z. Epub 2013 Sep 26.
7. Kachakova D, Mitkova A, Popov E, Beltcheva O, Vlahova A, Dikov T, Hristova S, Mitev V, Slavov C, Kaneva R .Evaluation of the clinical value of the newly identified urine biomarker HIST1H4K for diagnosis and prognosis of prostate cancer in Bulgarian patients. J BUON. 2013 Jul-Sep;18(3):660-8.
8. Р. Павлова, М. Петрова, Я. Желев, Е. Бояджиева, O. Белчева и Л. Трайков Аполипопротеин Еe4 и двигателни симптоми при пациенти с болест на Паркинсон с късно начало. Медицински преглед 2013, 49 (3), 57-62
9. Буева А, Белчева О, Маринова Св, Русинов Д, Бояджиева Е, Кънева Р, Митев В. Генетични изследвания при деца с кортикорезистентен чист нефротичен синдром, Уронет,
10. Буева А, Белчева О, Митева П, Пенчев В, Маринова С, Кънева Р, Митев В Генетика на вродените бъбречни аномалии, Уронет, 2012,1(1): 15-23.
11. Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantoj?rvi K, Karagiannidis I, Kos MZ, Kotyuk E, Laufer BI, Mantha K, McGregor NW, Meier S, Nieratschker V, Spiers H, Squassina A, Thakur GA, Tiwari Y, Viswanath B, Way MJ, Wong CC, O'Shea A, DeLisi LE. Selected rapporteur summaries from the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 14-18, 2012. Am J Med Genet B Neuropsychiatr Genet. 2013 Mar;162B(2):96-121
12. Beltcheva O, Boueva A, Morgunova E, Boiadjieva E, Marinova S, Kaneva R and Mitev, V. Novel mutation in Wilms tumour 1 gene associated with 6 steroid-resistant nephrotic syndrome, Nephrol Dial Transplant Plus, 2011.
13. Nikolov MA, Beltcheva O, Galabova A, Ljubenova A, Jankova E, Gergov G, Russev AA, Lynskey MT, Nelson EC, Nesheva E, Krasteva D, Lazarov P, Mitev VI, Kremensky IM, Kaneva RP, Todorov AA. No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample. Drug Alcohol Depend. 2011 Aug 1;117(1):62-5
14. Beltcheva O, Hj?rleifsd?ttir EE, Kontusaari S and Tryggvason, K. Sp1 specifically binds to an evolutionarily conserved DNA segment within a region necessary for podocyte-specific expression of nephrin. Nephron Exp Nephrol; 2010; 4 (1), 17-19
15. Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, D?rk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, … Slavov C, Mitkova A, … Popov E, Kachakova D, Dodova R, Belcheva O, Nikolov M, Mitev V,… Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116-21.
16. Beltcheva O, Kontusaari S, Fetissov S, Putaala H, Kilpel?inen P, H?kfelt T, Tryggvason K.Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin. J Am Soc Nephrol. 2003 Feb;14(2):352-8.
17. Beltcheva O, Martin P, Lenkkeri U, Tryggvason K.Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome. Hum Mutat. 2001 May;17(5):368-73
18. Todorova A, Ashikov A, Beltcheva O, Tournev I, Kremensky I.C283Y mutation and other C-terminal nucleotide changes in the gamma-sarcoglycan gene in the Bulgarian Gypsy population. Hum Mutat. 1999;14(1):40-4.
presentations:
1. Етични и правни аспекти на генетичните изследвания, доклад изнесен на Деветата национална конференция по етика с международно участие „Европейските етични стандарти и българската медицина”, София, 25-26 октомври, 2014,
2. O. Beltcheva, V. Penchev, A. Boueva, G. Zlatanova, G. Stancheva, T. Goranova, V. Mitev, R. Kaneva. Array CGH analysis of Bulgarian patients with multiple congenital pathologies including anomalies of kidney and urinary tract, European Society of Human Genetics Conference, Paris, France, 8-11 June, 2013
3. V. Penchev, O. Beltcheva, A. Boueva, H. Rendakova, G. Zlatanova, R. Kaneva, V. Mitev. Mutations in TCF and PAX genes are a rare cause for Congenital Anomalies of Kidney and Urinary Tract (CAKUT) in Bulgarian patients. European Society of Human Genetics Conference, Paris, France, 8-11 June, 2013
4. K. Mihova, S. Mehrabian, E. Boiadjieva, O. Beltcheva, R. Pavlova, Y. Zhelev, R. Kaneva, A. Jordanova,, V. Mitev, L. Traykov Association of ApoE polymorphisms in Bulgarian patients with Alzheimer disease and Frontotemporal dementia. European Society of Human Genetics Conference, Paris, France, 8-11 June, 2013
5. Beltcheva O, Cebir G, Nikolov M, Boiadjieva E, Galabova A, Ljubenova A, Jankova E, Krasteva D,Mitev V, Kremensky I, Kaneva R and Todorov A.Association study of the serotonin transporter polymorphism rs12150214 with heroin addiction in Bulgarian Roma XX th World Congress of Psychiatric Genetics, Hamburg, Germany, 14-18 October 2012
6. Cebir G, Nikolov M, Beltcheva O, Boiadjieva E, Galabova A, Ljubenova A, Jankova E, Krasteva D,Mitev V, Kremensky I, Kaneva R and Todorov A, Association analysis of serotonin transporter promoter polymorphisms with heroin abuse in Bulgarian and Roma subjects, XXth World Congress of Psychiatric Genetics, Hamburg, Germany, 14-18 October 2012
7. Beltcheva O, M Boyadzhieva, I Atanasova, O Angelova, R Kaneva, V Mitev. Association of a single nucleotide polymorphism in the adiponectin gene (ADIPOQ) with gestational diabetes mellitus in Bulgarian population. European Society of Human Genetics Conference, N?rnberg, Germany, 23-26.05.2012
8. Beltcheva O, M. Nikolov, A. Galabova, A. Ljubenova, E. Yankova, D. Krasteva, V. Mitev, I. Kremensky, R., A. Todorov Association study of BDNF single-nucleotide polymorphisms with heroin addiction in Bulgaria, 18thWorld Congress on Psychiatric Genetics, October 3-7, 2010, Athens, Greece
9. Nikolov M, O. Beltcheva, D. Krasteva, E. Yankova, V. Mitev, R. Kaneva, M. Lynskey, I. Kremensky, A. Todorov Association study of OPRM1 and heroin dependence in a large Bulgarian sample, 18thWorld Congress on Psychiatric Genetics, October 3-7, 2010, Athens, Greece
10. Penchev V., O. Beltcheva, A. Boueva, P. Miteva, R. Kaneva, V. Mitev; Screening of TCF2 and PAX2 genes for mutations associated with congenital anomalies of the kidney and urinary tract in Bulgarian patients. European Society of Human Genetics Conference, Amsterdam, the Netherlands, May 28-31, 2011, p. 277
11. Beltcheva O., Boiadjieva E., Boueva A., Marinova S., Kaneva R., Mitev V., A novel WT1 mutation identified in a patient with steroid-resistant nephrotic syndrome, European Human Genetics Conference, June 12 – June 15, 2010, Gothenburg, Sweden.
12. Nikolov M., Kaneva R., Beltcheva O., Todorov A., Mitev V., Kremensky I. (2009) Candidate genes, associated with heroin dependence in Bulgarian population. Poster presentation. 8th Balkan Meeting on Human Genetics, 14 – 17 May 2009 Cavtat, Croatia
13. Beltcheva O, Botev P, Savov A, Zaharova B, Kaneva R, Kremensky I. (2008) Frequency of the R229Q functional variant in NPHS2, associated with increased risk for microalbuminuria, in Bulgarian Roma population. Poster presentation. P07.098. European Human Genetics Conference, May 31 – June 3, Barcelona, Spain.
