About us / Management
Acad. Prof. Vanio Mitev, MD, PhD, DSc.
E-mail: mitev@medfac.acad.bg
Education:
1998 Professor - Dept. Chemistry and Biochemistry, MU-Sofia
1997 Doctor of science - Dept. Chemistry and Biochemistry, MU-Sofia
1995 Assoc. Professor - Dept. Chemistry and Biochemistry, MU-Sofia
1987 PhD - Dept. Chemistry and Biochemistry, MU-Sofia
1982 MD - Medical University of Sofia, Faculty of medicine
Previous and Current Employment:
2008 Rector of Medical University - Sofia
2003-2008 Head of Dept. International integration - MU-Sofia
1998-2003 Vice-dean of science Medical Faculty, MU-Sofia
1999 Head of department - Dept. Chemistry and Biochemistry, MU-Sofia
1999 Section head - Dept. Chemistry and Biochemistry, MU-Sofia
Language proficiency:
English, French, Russian
Research interests:
Protein kinases, keratinocytes, proliferation, differentiation, apoptosis, bioactive compounds
Professional and Scientific Awards:
American Dermatology association 1992
American Dermatology association 2000
Medical University of Sofia Award Orahovac 2005
Participation in research projects:
Principal Investigator
2009-2013 National University Complex in Biomedical and Translational Research, infrastructural project, National Science Fund, Ministry of Education and Science
2009-2010 Enhancing the capacity of the cores Cell and Tissue Cultures, Microarray and Laser Microdissection in Molecular Medicine Center, MU - Sofia, infrastructural project, 8I-2009
2008-2009 Evaluation of the relevance of the beta-catenin (CTNNB1) gene mutation analysis for patients with endometrial cancer
Co-Investigator
2010-2011 Study of the molecular basis of congenital anomalies of the kidney and urinary tract (CAKUT) in Bulgaria. Role of Pax2 for the pathogenesis of CAKUT, MU-Sofia, A/Prof. Bueva
2010-2011 Investigation of the diagnostic specificity of promoter hypermethylation of biomarkers in urine, associated with prostate cancer in Bulgarian patients, MU-Sofia, Prof. Ch. Slavov
2009-2012 Contemporary approaches for unravelling the genetic basis of epilepsy National Science Fund, Ministry of Education and Science, DTK 02-67/2009, PI Prof. A. Jordanova
2009-2012 Clinical and molecular markers with predictive value for survival, quality of life and treatment response in high-grade gliomas, National Science Fund, Ministry of Education and Science, DTK 02-49/2009, PI A/Prof. N. Gabrovsky
2009-2010 Analysis of big deletions, insertions and rearrangements in BRCA1 and BRCA2; MU-Sofia
2009-2010 Analysis of polymorphic variants in candidate genes associated with prostate cancer; MU-Sofia
Publications:
1. Todorov T, Todorova A, Georgieva B, Mitev V. A unified rapid PCR method fordetection of normal and expanded trinucleotide alleles of CAG repeats in huntington chorea and CGG repeats in fragile X syndrome. Mol Biotechnol. 2010 Jun;45(2):150-4.
2. Guenova E, Volz T, Eichner M, Hoetzenecker W, Caroli U, Griesinger G, Burow G, Mitev V, Biedermann T. Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly. Allergy. 2010 Feb 1. [Epub ahead of print]
3. Poumay Y, Mitev V. Members of the EGF receptor family in normal and pathological epidermis. Folia Med ( Plovdiv ). 2009 Jul-Sep;51(3):5-17. Review.
4. Kirilov G, Zacharieva S, Alexandrov AS , Lozanov V, Mitev V. Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: a comparison with plasma homocysteine. Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):457-61.
5. Konstantinova D, Kaneva R, Dimitrov R, Savov A, Ivanov S, Dyankova T, Kremensky I, Mitev V. Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer. DNA Cell Biol. 2010 Feb;29(2):65-70.
6. Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, HopperJL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL,Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY,Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, OBrien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC,Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL,Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM,Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J,Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A,Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116-21. Epub 2009 Sep 20.
7. Benkova B, Lozanov V, Ivanov IP, Mitev V. Evaluation of recombinant caspase specificity by competitive substrates. Anal Biochem. 2009 Nov 1;394(1):68-74. Epub 2009 Aug 3.
8. Konstantinova DV, Kadiyska TK, Kaneva RP, Tosheva EG, Guseva VT, Dimitrov BH, Dimitrov RG, Doganov NI, Ivanov SI, Kremensky IM, Mitev VI. CHEK2 I157T and endometrial cancer. DNA Cell Biol. 2009 Jan;28(1):9-12. PubMed PMID: 18834326.
9. Kirilov, G., Zacharieva, S., Alexandrov, A.S., Lozanov, V., Mitev, V., 2009, Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: A comparison with plasma homocysteine, Methods and Findings in Experimental and Clinical Pharmacology 31 (7), pp. 457-461
10. Benkova, B., Lozanov, V., Ivanov, I.P., Mitev, V., 2009, Evaluation of recombinant caspase specificity by competitive substrates,Analytical Biochemistry 394 (1), pp. 68-74
11. Benkova, B., Lozanov, V., Ivanov, I.P., Kalenderova, S., Stoev, G., Yordanova, N., Milchova, M., Mitev, V., 2009, Quantitation of the homocysteine content in wine, European Food Research and Technology 230 (2), pp. 361-365
12. Isaeva AR , Mitev VI (2009).Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes. J Dermatol Sci., April 29
13. Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev V.,2009, Investigation on the influence of certain additives to the electrode solutions for improvement of isoelectric focusing, Comptes Rendus de LAcademie Bulgare des Sciences 62 (9), pp. 1095-1102
14. Mateva, L., Petrov, S., Elenkova, A., Zacharieva, S., Mitev V., 2009, Plasma and urinary catecholamines and metanephrines in the diagnosis of autonomic disorders, Comptes Rendus de LAcademie Bulgare des Sciences 62 (7), pp. 905-912
15. Naydenov, C.L., Kirazov, E.P., Lozanov, V.S., Kirazov, L.P., Mitev, V.I., 2008, Electrochemical reactions during isoelectric focusing and their role in establishment of the pH gradient, Chromatographia 69 (9-10), pp. 887-895
16. Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev, V., 2008, Electrochemical explanation of the pH gradient drifts during isoelectric focusing, Comptes Rendus de LAcademie Bulgare des Sciences 61 (12), pp. 1561-1566
17. Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev, V., 2008, Instabilities of the pH gradient during isoelectric focusing and their relationship with the electrochemical reactions occurring in the electrode solutions, Comptes Rendus de LAcademie Bulgare des Sciences 61 (7), pp. 899-904
18. Todorova, A., Guergueltcheva, V., Genova, J., Mihaylova, V., Todorov, T., Tchamova, T., Georgieva, B., (...), Mitev, V., 2009, Molecular diagnostics of duchenne/becker muscular dystrophy patients by multiplex ligation-dependent probe amplification analysis and direct sequencing, Balkan Journal of Medical Genetics 12 (2), pp. 3-9
19. Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev V., 2009, A criterion for the drive of the isoelectrofocusing system toward steady state, Comptes Rendus de LAcademie Bulgare des Sciences 62 (1), pp. 41-48
20. Guenova E, Weber HO, Voykov B, Metzler G, Mitev V, Berneburg M, Hoetzenecker W, Röcken M. (2008) Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease. Arch Dermatol., 144(8):1081-2
21. Todorova A, Todorov T, Georgieva B, Lukova M, Guergueltcheva V, Kremensky I, Mitev V. (2008) MLPA analysis/complete sequencing of the DMD gene in a group of Bulgarian Duchenne/Becker muscular dystrophy patients.Neuromuscul Disord.,Aug;18(8):667-70.
22. Ivanova P, Atanasova G, Poumay Y, Mitev V. (2008) Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation. Arch Dermatol Res., Mar;300(3):139-45.
23. Atanasova G, Isaeva A, Ivanova P, Kalenderova S, Poumay Y, V. Mitev. Pharmacological growth inhibition of papillomavirus type 16 E6E7-transformed keratinocytes by CDK-inhibitor CYC202. Comp Rend Acad Bulg Sci 60, №4, 2007, 183-189
24. Atanasova G, Isaeva A, Zh
